Formulation and Evaluation of Antifungal Drug Containing Mucoadhesive Tablet for Vaginal Candidiasis

Abstract: Objectives: Female population frequently seeks medical consultation for the vaginal candidiasis. Voriconazole (VOR) is a BCS class II antifungal drug with low aqueous solubility and hence inclusion complex was formulated using Hydroxypropyl-β-cyclodextrin (HPβCD). The incorporated into mucoadhesive tablet Chitosan Hydroxypropyl Methyl Cellulose (HPMC K100). Materials Methods: A 32 full factorial design employed sustained release Design expert® software. Results: Scanning Electron Microscopy (SEM) results indicated formation between HPβCD. batches showed 39.68±1.2 to 72.31±1.4% of 4 hr while 8 it from 77.23±1.5 99.82±1.1%. Therefore, achieved hr. had swelling % 228.51±12 323.11±8% strength 1131.02±49 2302.12±55 dyne/cm2. In in vitro activity study, higher zone inhibition observed complex-based (34±0.3 mm) as compared plain (25±0.4 mm). Conclusion: could be successfully by employing increased residence at site infection improved therapeutic efficacy. Keywords: Voriconazole, Factorial design, Inclusion complex, Vaginal Candidiasis, Sustained release, activity, release.